Total Bilirubin

Total bilirubin shows how well your liver clears bilirubin, a yellow pigment from red blood cells.

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Test Summary

Sample Type 
Blood
Required Blood
1 mL
Analysis Type
Serum
Collection method
In person at the lab; at-home where available

Why test

Total Bilirubin

?

Clinicians order total bilirubin to check liver and bile duct health, investigate yellowing of the skin or eyes, or dark urine. It also helps monitor known liver conditions and medicines that may affect the liver. Results often guide next steps, like fractionated (direct/indirect) bilirubin or a full liver panel. You can test this marker with Aniva across Germany and Finland.

What is

Total Bilirubin

?

Clinicians order total bilirubin to check liver and bile duct health, investigate yellowing of the skin or eyes, or dark urine. It also helps monitor known liver conditions and medicines that may affect the liver. Results often guide next steps, like fractionated (direct/indirect) bilirubin or a full liver panel. You can test this marker with Aniva across Germany and Finland.

What insights will i get from

Total Bilirubin

?

High: May suggest liver stress, slowed bile flow, increased red blood cell breakdown, or a common inherited pattern (Gilbert syndrome). Levels can rise with fasting, illness, or certain medicines. Consider repeat testing and checking direct bilirubin and liver enzymes. A simple step is to avoid alcohol and review medicines with your clinician.
Low: Usually not meaningful and needs no action.

Sample type & collection

  • Sample: Blood
  • Fasting: No
  • Best timing: Morning, for consistent trend comparisons
  • Collection: In person at the lab; at-home where available
  • Typical volume: 1 mL
  • Analysis: Serum
  • Prep tips: No fasting needed; stay hydrated. Protect sample from light.
  • Turnaround: 1–3 business days

Total Bilirubin

is best interpreted with:

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Total Bilirubin

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Limits & interferences with

Total Bilirubin

:

Common factors include fasting or very low-calorie diets, dehydration, strenuous exercise, recent illness, alcohol, and pregnancy. Drugs like rifampin, atazanavir, indinavir, probenecid, and some antibiotics can raise levels; high-dose vitamin C may falsely lower them. Hemolysis in the tube and exposure of the sample to light can skew results; taking the sample at a consistent time helps with trends.

Special situations include pregnancy, newborn testing, and known Gilbert syndrome—confirm with repeat or fractionated bilirubin and discuss context with your clinician.

Questions about

Total Bilirubin

:

What does a high total bilirubin mean? It often means the liver is not clearing bilirubin well, bile flow is slowed, or red blood cell breakdown is increased.

Do medications or supplements affect results? Yes. Some antibiotics, HIV medicines, and rifampin can raise it. High-dose vitamin C may falsely lower it.

Do I need to fast for this test? No. Fasting is not required, though very strict fasting can temporarily raise levels.

How often should I test? As advised by your clinician. It’s often checked with a liver panel for symptoms or when monitoring medicines or known liver disease.

How long do results take? Most labs report results within 1–3 business days.

What should I discuss with my clinician? Share symptoms, medication and supplement use, alcohol intake, recent illnesses, and any history of Gilbert syndrome.

Sources:

  • MedlinePlus — Bilirubin Blood Test. (2024). https://medlineplus.gov/lab-tests/bilirubin-blood-test/
  • NHS — Liver function test. (2023). https://www.nhs.uk/conditions/liver-function-test/
  • NIDDK — Liver Tests. (2023). https://www.niddk.nih.gov/health-information/diagnostic-tests/liver-tests
  • ARUP Consult — Jaundice in Adults. (2024). https://arupconsult.com/content/jaundice-adults
  • AASLD — How to approach elevated liver enzymes. (2023). https://www.aasld.org/liver-fellow-network/core-series/back-basics/how-approach-elevated-liver-enzymes
Medical disclaimer: This content is for informational purposes only and is not medical advice. Always discuss results with a qualified healthcare professional.

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